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Transcriptomic analysis of pancreas from Elp3 epithelial-specific knockout and wild-type mice with and without caerulein treatment

GSE296464 Mus musculus (mouse) RNA-seq (gene expression) 16 samples Submitted 2025/12/04 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 16 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
16 samples: 4 × Control pancreas - Elp3KO - Mmu vs 4 × Control pancreas - Elp3WT - Mmu vs 4 × Caerulein pancreatitis - Elp3KO - Mmu vs 4 × Caerulein pancreatitis - Elp3WT - MmuGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Upregulation of ELP3 in acinar cells during acute pancreatitis is dispensable for homeostasis, inflammation, regeneration, and cancer initiationScientific reports · 2025
Summary (written by the submitters)
To study the role of Elp3 in pancreatic homeostasis and pancreatitis, pancreas tissues were collected from Elp3(fl/fl); Pdx-Cre and wild-type mice either untreated or after caerulein-induced pancreatitis. RNA sequencing was performed to identify transcriptional changes associated with Elp3 loss and pancreatic injury.
Published in
Upregulation of ELP3 in acinar cells during acute pancreatitis is dispensable for homeostasis, inflammation, regeneration, and cancer initiation
Aajja E, Lefort H, Mahibullah S et al. · Scientific reports 2025 · PMID 41198876 · doi:10.1038/s41598-025-22849-8
This dataset
Open GSE296464 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296464_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1259428 and SRA study SRP583361. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41198876) ↗
Study design
4 × Control pancreas - Elp3KO - Mmu vs 4 × Control pancreas - Elp3WT - Mmu vs 4 × Caerulein pancreatitis - Elp3KO - Mmu vs 4 × Caerulein pancreatitis - Elp3WT - Mmu

Supports a between-group comparison across 16 samples.

How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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