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Fos binding in hippocampal chromain 1 h after peritoneal KA administration

GSE285372 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 7 samples Submitted 2025/09/17 Platform GPL17021
Summary
Fos induction is the most commonly used marker of neuronal activation. Here, we investigate the binding profile of Fos in the adult mouse hippocampus using antibodies specific against this transcription factor and the chromatin Immunoprecipitation coupled to DNA-sequencing (ChIP-seq) method. We generated profiles in basal conditions and 1 hour after neuronal stimulation. To trigger the syncronous activation of hippocampal exciatory neurons we treated the mice with kainic acid (KA) through peritoneal administration. This model of status epilepticus has been characterized in detail at the epigenomic level (Fernandez-Albert et al., 2019).
Published in
Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions
Alaiz-Noya M, Miozzo F, Fuentes-Ramos M et al. · Nature communications 2025 · PMID 41193527 · doi:10.1038/s41467-025-65343-5
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Also filed as BioProject PRJNA1203241 and SRA study SRP553916. Searching any of these in the dataset finder brings you back here.

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