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Parishin B Blocking TRIB3-AKT1 interaction inhibits Breast cancer Lung Metastasis

GSE285440 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/27 Platform GPL24676
Summary
TRIB3 has been reported to mediate breast cancer (BC) proliferation and metastasis by interacting with AKT1, and blocking the interaction between TRIB3 and AKT1 can inhibit the progression of BC. Besides, inhibiting TRIB3 to turn “cold tumor” hot has also been proved to be an effective therapeutic strategy for BC. Thus, this study aim to find drugs that can bind to TRIB3 to inhibit BC progression, and further elucidate its mechanism.
Published in
Parishin B blocking TRIB3-AKT1 interaction inhibits breast cancer lung metastasis
Cheng X, Sun J, Chen S et al. · Frontiers in pharmacology 2024 · PMID 39881875 · doi:10.3389/fphar.2024.1517708
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Also filed as BioProject PRJNA1203633 and SRA study SRP554093. Searching any of these in the dataset finder brings you back here.

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