GEO series
Endothelial transcription factor EB protects against doxorubicin-induced endothelial toxicity and cardiac dysfunction
GSE285475
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2025/12/18
GPL24247
Summary
Doxorubicin (DOX) has been demonstrated to induce cardiovascular toxicity in cancer survivors. Endothelial cell dysfunction is recoginized to play a critical role in the onset and severity of cardiotoxicity associated with DOX. Endothelial TFEB protects against EC damage and cardiac dysfunction. Cardiac single cells isolated from vehicle and doxorubicin treated wild type and EC-Tfeb Tg mice were collected for scRNA-seq analysis.
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Paper (PMID 41410033) ↗
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