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Global alternative RNA splicing analysis of Epstein-Barr Virus EBNA1-regulated cells

GSE285484 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/04 Platform GPL35254
Summary
Purpose: To identify the effect of EBV EBNA1 on cellular mRNA alternative splicings Methods: HEK293 cells were transfected with either Flag-EBNA1 vector or empty vector (NC) for 48 hours. Then the cell RNA was sequenced by a PromethION platform (P48-seq, the third generation sequencing). Results: Log-fold changes of up- or down-regulated mRNAs between the control and experiment group were selected with a significance threshold of p<0.05. Conclusions: Our study describes the mRNA alternative splicing changes induced by EBV-EBNA1 in HEK293 cells
Published in
A Prion-Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing
Zhang X, Li Z, Zheng R et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 40729735 · doi:10.1002/advs.202501977
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Also filed as BioProject PRJNA1203917 and SRA study SRP554214. Searching any of these in the dataset finder brings you back here.

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