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Functional reprogramming of neutrophils within tumors by hypoxia-driven histone lactylation [scRNA-seq]

GSE285510 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/14 Platform GPL24247
Summary
We used scRNAseq to study the mechanism underlying the functional reprogramming in brain tumors. scRNA-seq of FACS-sorted neutrophils was performed on mice with brain tumors (SB28). We showd that the immunosuppressive ability of brain-tumor infiltrating neutrophils was exclusively mediated by a population of highly glycolytic neutrophils expressing the transferrin receptor CD71.
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Also filed as BioProject PRJNA1204119 and SRA study SRP554311. Searching any of these in the dataset finder brings you back here.

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