Effects of PD-L1 silencing on global transcriptomic changes in tumor
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Improving IL12 immunotherapy in glioblastoma by targeting the long noncoding RNA INCR1Journal of neuro-oncology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285565_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1204396 and SRA study SRP554563. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8704926 siNC-C1 siNC-C
- GSM8704927 siNC-C2 siNC-C
- GSM8704928 siNC-IFN1 siNC-IFN
- GSM8704929 siNC-IFN2 siNC-IFN
- GSM8704930 siPDL1-1-C1 siPDL1-1-C
- GSM8704931 siPDL1-1-C2 siPDL1-1-C
- GSM8704932 siPDL1-1-IFN1 siPDL1-1-IFN
- GSM8704933 siPDL1-1-IFN2 siPDL1-1-IFN
- GSM8704934 siPDL1-2-C1 siPDL1-2-C
- GSM8704935 siPDL1-2-C2 siPDL1-2-C
- GSM8704936 siPDL1-2-IFN1 siPDL1-2-IFN
- GSM8704937 siPDL1-2-IFN2 siPDL1-2-IFN
- GSE334189 RNA-seq analysis of global gene expression changes in human FSHD immortalized myotubes following treatment with the BAZ1A inhibitor C06 18 samples shares changes, global
- GSE319722 Spatial dynamics links PD-L1 and Tumor-Associated Macrophage–Enriched Niches to Immune and Mesenchymal States in microsatellite stable colorectal cancer 117 samples shares pd-l1
- GSE286827 4-1BB+ Tregs and inhibitory progenitor exhausted T cells confer resistance to anti-PD-L1 and anti-CTLA-4 combination therapy 87 samples shares pd-l1
- GSE306800 Extracellular matrix-myCAF signatures correlate with resistance to neoadjuvant aPD-L1 immune checkpoint inhibition with durvalumab + metformin in HPV+ HNSCC 18 samples shares pd-l1
- GSE295042 The Role of PD-1/PD-L1 in Overshooting Osteoclastogenesis in Periprosthetic Joint Infections 12 samples shares pd-l1
- GSE279750 ACE2 Enhances Sensitivity to PD-L1 Blockade by Inhibiting Macrophage-Induced Immunosuppression and Angiogenesis [RNA-seq, anti-PD-L1 therapy] 10 samples shares pd-l1
- GSE287078 Time- and Dose-Dependent Effects of Irradiation on Endothelial and Tumor Endothelial Cells: Transcriptional, Molecular, and Functional Changes Driving Activation In Vitro and In Vivo 30 samples shares changes
- GSE314805 Prostate Tumor Immune Microenvironment Changes Following Immunotherapy Shared by Patients who Developed Anti-Tumor Response or Immune-Related Adverse Events 24 samples shares changes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.