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NELFCD: A Crucial Factor in Uveal Melanoma Cell Proliferation and Tumorigenesis

GSE285583 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/07 Platform GPL16791
Summary
Uveal melanoma is the most common intraocular malignant tumour in adults.Posterior uveal melanoma is highly likely to metastasise to the liver (89%), lungs (29%), bone (17%), skin and subcutaneous tissues (12%), and lymph nodes (11%) and has an extremely high mortality rate.Due to the unclear pathogenesis, there is still no effective treatment for uveal melanoma other than surgery.Thus, it is crucial to investigate the mechanisms of carcinogenesis and proliferation of uveal melanoma.Recent evidence suggests that biomolecular condensates,membrane-free cellular compartments formed by liquid-liquid phase separation (LLPS), plays crucial roles in physiological and tumorigenic processes.The aim of this study was to investigate the role of LLPS in the development of uveal melanoma in order to explore potential therapeutic targets for UM.
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Direct links to NCBI, no account and no request form: the whole study as GSE285583_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1204924 and SRA study SRP554661. Searching any of these in the dataset finder brings you back here.

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