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Effect of kinsenoside on bone marrow-derived macrophages during acute pancreatitis

GSE285782 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/27 Platform GPL24247
Summary
Studies have shown that the small molecular compound kinsenoside (KD) can inhibit the M1 polarization of macrophages and inhibit the expression of proinflammatory genes. However, the role of kinsenoside in acute pancreatitis is unclear. Our study showed that intraperitoneal injection of kinsenoside can alleviate acute pancreatitis in mice. In order to find out the main mechanism by which kinsenoside affects the polarization of macrophages in acute pancreatitis, we further performed transcriptomic analysis of bone marrow-derived macrophages (BMDMs) stimulated by injured pancreatic acinar cell conditioned media (PAC-CM) treated with or without kinsenoside. This work provides a potential therapeutic approach for acute pancreatitis.
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Also filed as BioProject PRJNA1206079 and SRA study SRP555098. Searching any of these in the dataset finder brings you back here.

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