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Multi-omics of resting and anti-CD3/CD28-stimuated Jurkat cells

GSE285832 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 46 samples Submitted 2025/09/01 Platform GPL20795Platform GPL24676
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 46 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Samples
46 samples: 22 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activationScience advances · 2026
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation
Wang Z, Dong W, Feng X et al. · Science advances 2026 · PMID 41477821 · doi:10.1126/sciadv.ady2539
This dataset
Open GSE285832 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285832_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1206166 and SRA study SRP531503. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41477821) ↗
Study design
22 conditions, mostly in duplicate
Jurkat cell resting RNA-seq ×2 Jurkat cell stimulated RNA-seq ×2 Jurkat cell resting ATAC-seq ×2 Jurkat cell stimulated ATAC-seq ×2 Jurkat cell resting Capture HiC ×2 Jurkat cell stimulated Capture HiC ×2 Jurkat cell resting ChIP-seq Input ×2 Jurkat cell resting ChIP-seq H3K27ac ×2 +16 more

Supports a between-group comparison across 44 samples.

How we read this: 22 replicated groups read from 46 sample titles; they account for 44 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 6 more — browse all 46 samples with per-sample file links →

Datasets on a similar topic

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.