EZH1/EZH2 Inhibition Enhances Adoptive T-cell Immunotherapy Against Multiple Cancer Models
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × SUDHL4-DMSO-UTD vs 3 × SUDHL4-TAZ-UTD vs 3 × SUDHL4-DMSO-CART19 vs 3 × SUDHL4-TAZ-CART19Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer modelsCancer cell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285897_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1206723 and SRA study SRP555374. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8712290 SUDHL4-DMSO-UTD-REP1 SUDHL4-DMSO-UTD
- GSM8712291 SUDHL4-DMSO-UTD-REP2 SUDHL4-DMSO-UTD
- GSM8712292 SUDHL4-DMSO-UTD-REP3 SUDHL4-DMSO-UTD
- GSM8712293 SUDHL4-TAZ-UTD-REP1 SUDHL4-TAZ-UTD
- GSM8712294 SUDHL4-TAZ-UTD-REP2 SUDHL4-TAZ-UTD
- GSM8712295 SUDHL4-TAZ-UTD-REP3 SUDHL4-TAZ-UTD
- GSM8712296 SUDHL4-DMSO-CART19-REP1 SUDHL4-DMSO-CART19
- GSM8712297 SUDHL4-DMSO-CART19-REP2 SUDHL4-DMSO-CART19
- GSM8712298 SUDHL4-DMSO-CART19-REP3 SUDHL4-DMSO-CART19
- GSM8712299 SUDHL4-TAZ-CART19-REP1 SUDHL4-TAZ-CART19
- GSM8712300 SUDHL4-TAZ-CART19-REP2 SUDHL4-TAZ-CART19
- GSM8712301 SUDHL4-TAZ-CART19-REP3 SUDHL4-TAZ-CART19
- GSE270684 The EZH2 and EZH1 inhibitor valemetostat derepresses p16INK4a to induce early endomitotic exit in megakaryocytes [scATAC-Seq] 66 samples shares ezh1, ezh2
- GSE293546 EZH2 inhibitor SHR2554 enhances the anti-tumor efficacy of HDAC inhibitor Chidamide through STAT1 in T-cell lymphoma 34 samples shares ezh2, enhances
- GSE193413 Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth [Hi-C] 28 samples shares ezh2, inhibition
- GSE237951 Inhibition of EZH2 restores normal expression of genes associated with cysteine metabolism and ferroptosis in hepatocellular carcinoma [RNA-seq] 8 samples shares ezh2, inhibition
- GSE300177 Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia 194 samples shares inhibition, enhances
- GSE266219 Clinical and Immunological Responses to Combined JAK Inhibition and PD-1 immunotherapy for Lung Cancer Patients 79 samples shares immunotherapy, inhibition
- GSE306221 Transient inhibition of MEK/ERK and WNT pathways enhances direct differentiation of primed hPSCs into functional trophoblast stem cells 18 samples shares inhibition, enhances
- GSE253327 HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [RNA-Seq_QJ8080] 15 samples shares immunotherapy, multiple
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.