GEO series
EZH1/EZH2 Inhibition Enhances Adoptive T-cell Immunotherapy Against Multiple Cancer Models
GSE285897
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2025/03/15
GPL30173
Summary
Tumor resistance to chimeric antigen receptor T-cell (CART) therapy is a major challenge. Epigenetic modulation, which rewires cancer cells to a more immunogenic phenotype, could improve adoptive T cell (ACT) efficacy. This study hypothesized that inhibiting EZH2 would enhance ACT. In Germinal Center-derived B-cell human lymphoma models, EZH2 inhibition with tazemetostat improved anti-CD19 CART (CART19) tumor control. The goal of this experiment is to test is tazemetostat-treated tumors showed chromatin opening at genes related to cell-cell adhesion, B-cell activation, and inflammatory responses.
Download
NCBI GEO page ↗
Paper (PMID 39983725) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
human ChIP / ATAC / CUT&Tag datasets →
Similar datasets
- GSE316079 SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome [ATAC-seq] 6 samples
- GSE334112 Reversible epiblast regionalisation determines differentiation potential of human PSCs [ATAC-seq] 38 samples
- GSE329512 SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry 19 samples
- GSE318107 CAD-C: An engineered nuclease enables repair-free in situ proximity ligation and nucleosome-resolution chromosome walks in human cells [Cut & Tag] 10 samples
- GSE316989 Targeting CDK12/CYCLIN K induces a gene activation program which is mediated by P-TEFb [Cut&RUN] 10 samples
- GSE142751 Genome-wide maps of chromatin state in 142 cancer cell lines [cell line] 855 samples
- GSE327821 Single-molecule, single-cell profiling of linked chromatin states [Single_cell_CoCUT&Tag] 200 samples
- GSE339365 Genome-wide H3K4me3 profiling of circulating immune cells reveals dynamic epigenetic reprogramming during acute critical COVID-19 120 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.