Oligodendrocyte precursor cells facilitate neuronal lysosome release
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × OPC, ctl mice vs 3 × OPC, dKO mice vs 3 × Neuron, ctl mice vs 3 × Neuron, dKO miceGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Oligodendrocyte precursor cells facilitate neuronal lysosome releaseNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285995_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1207448 and SRA study SRP555744. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8714627 OPC, ctl mice 1 OPC, ctl mice
- GSM8714628 OPC, ctl mice 2 OPC, ctl mice
- GSM8714629 OPC, ctl mice 3 OPC, ctl mice
- GSM8714630 OPC, dKO mice 1 OPC, dKO mice
- GSM8714631 OPC, dKO mice 2 OPC, dKO mice
- GSM8714632 OPC, dKO mice 3 OPC, dKO mice
- GSM8714633 Neuron, ctl mice 1 Neuron, ctl mice
- GSM8714634 Neuron, ctl mice 2 Neuron, ctl mice
- GSM8714635 Neuron, ctl mice 3 Neuron, ctl mice
- GSM8714636 Neuron, dKO mice 1 Neuron, dKO mice
- GSM8714637 Neuron, dKO mice 2 Neuron, dKO mice
- GSM8714638 Neuron, dKO mice 3 Neuron, dKO mice
- GSE290816 Cell autonomous regional differences in oligodendrocyte precursor cell development and response to oncohistone H3.3 K27M [RNA-seq] 142 samples shares oligodendrocyte, precursor
- GSE297344 Analysis of a BCOR internal tandem duplication in mouse embryonic stem cell to neuronal precursor differentiation 30 samples shares precursor, neuronal
- GSE290817 Cell autonomous regional differences in oligodendrocyte precursor cell development and response to oncohistone H3.3 K27M [scRNA-seq] 22 samples shares oligodendrocyte, precursor
- GSE300591 Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis 15 samples shares oligodendrocyte, precursor
- GSE241211 Oligodendrocyte precursor cell regulates microglial transition to neuroprotective phenotype by BMP4 driven acquisition of disease associated state in Alzheimer’s disease 12 samples shares oligodendrocyte, precursor
- GSE310482 Cell autonomous regional differences in oligodendrocyte precursor cell development and response to oncohistone H3.3 K27M 217 samples shares oligodendrocyte, precursor
- GSE310474 Cell autonomous regional differences in oligodendrocyte precursor cell development and response to oncohistone H3.3 K27M [ChIP-Seq] 40 samples shares oligodendrocyte, precursor
- GSE255407 Single cell approaches define two mammalian oligodendrocyte precursor cell populations and their evolution over developmental time [Xenium In Situ Gene Expression] 3 samples shares oligodendrocyte, precursor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.