Reprogramming intratumoral Tregs by morpholino-mediated splicing of FOXP3 for cancer immunotherapy
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 4 × Mut vs 3 × WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Reprogramming intratumoral T(reg) cells by morpholino-mediated splicing of FOXP3 for cancer immunotherapyScience immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286047_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1207540 and SRA study SRP555820. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 7 samples.
How we read this: 2 replicated groups read from 14 sample titles; they account for 7 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8716970 Mut1 Mut
- GSM8716971 Mut2 Mut
- GSM8716972 Mut3 Mut
- GSM8716973 Mut4 Mut
- GSM8716974 WT1 WT
- GSM8716975 WT2 WT
- GSM8716976 WT4 WT
- GSM8716977 Mut1_TCR
- GSM8716978 Mut2_TCR
- GSM8716979 Mut3_TCR
- GSM8716980 Mut4_TCR
- GSM8716981 WT1_TCR
- GSM8716982 WT2_TCR
- GSM8716983 WT4_TCR
- GSE304763 A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions [scTCR_immunotherapies] 91 samples shares immunotherapy, intratumoral
- GSE251931 Maintenance of tolerance after lung transplantation is dependent on the preservation of allograft tissue-resident Foxp3+ T cells 15 samples shares foxp3
- GSE149674 Dynamic Foxp3-chromatin interaction controls tunable Treg cell function 94 samples shares foxp3
- GSE297451 Temporal and Context-Dependent Requirements for the Transcription Factor Foxp3 in Regulatory T Cell Development and Maintenance [RNA-seq] 70 samples shares foxp3
- GSE311963 CD38 endows local antigen-specific Foxp3+ Treg cells with stress resilience for compartmentalized control of CNS inflammation 68 samples shares foxp3
- GSE267882 Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation [ChIP-Seq] 34 samples shares foxp3
- GSE229592 Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity 32 samples shares foxp3
- GSE267881 Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation [ATAC-Seq] 30 samples shares foxp3
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.