Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges [RNA-seq]
Single-cell RNA-seq · mouse · 10 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 10 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challengeseLife · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286073_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1207582 and SRA study SRP555884. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 10 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8717389 CK1 WT control mouse liver, Fed
- GSM8717390 CK2 WT control mouse liver, Fed
- GSM8717391 CKZ1 Hepatocyte RIPK1 konck out mouse liver,Fed
- GSM8717392 CKZ2 Hepatocyte RIPK1 konck out mouse liver,Fed
- GSM8717393 T11 WT control mouse liver, Fasted 12h
- GSM8717394 T12 WT control mouse liver, Fasted 12h
- GSM8717395 T13 WT control mouse liver, Fasted 12h
- GSM8717396 T21 Hepatocyte RIPK1 konck out mouse liver, Fasted 12h
- GSM8717397 T22 Hepatocyte RIPK1 konck out mouse liver, Fasted 12h
- GSM8717398 T23 Hepatocyte RIPK1 konck out mouse liver, Fasted 12h
- GSE279700 Cooperation of TRADD- and RIPK1-dependent Cell Death Pathways in Maintaining Intestinal Homeostasis [3 DPI colon] 35 samples shares ripk1, maintaining, homeostasis
- GSE238201 Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [RNA-seq] 12 samples shares homeostasis, rna-seq, liver
- GSE285614 Adipocyte death drives fat redistribution from adipocytes to hepatocytes in steatotic liver disease via S100A8+ macrophages [RNA-seq] 34 samples shares hepatocyte, rna-seq, liver
- GSE245632 Generation and characterization of mature hepatocyte organoids for liver metabolic studies 45 samples shares hepatocyte, liver
- GSE263415 Spatial hepatocyte plasticity of gluconeogenic gene expression and gluconeogenic activity during the metabolic transitions between fed, fasted and starvation states [RNA-Seq] 18 samples shares hepatocyte, rna-seq
- GSE228579 Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling 66 samples shares homeostasis, liver
- GSE266509 A Bcl11a-driven mechanism maintaining hematopoietic stem cell functionality gives rise to dysfunction during aging [RNA-Seq] 52 samples shares maintaining, rna-seq
- GSE294857 Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10] 31 samples shares hepatocyte, liver
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.