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The Transcription Factor T-bet Plays a Crucial Role in Regulating the Immune Regulatory Function of Double-Negative T Cells

GSE286125 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/01/01 Platform GPL17021
Summary
This study found that, compared to conventional CD4+ / CD8+ T cells, double-negative T (DNT) cells express high levels of IFN-γ, and IFN-γ can dose-dependently enhance the in vitro conversion efficiency of DNT cells, suggesting that DNT cells tend to adopt a Th1 phenotype. Single-cell sequencing revealed that DNT cells exhibit high expression of the transcription factor T-bet. Knockout of T-bet significantly downregulated IFN-γ expression in DNT cells and reduced their suppressive capacity on macrophages in vitro. Transcriptome sequencing further elucidated the specific mechanism by which T-bet regulates the immune regulatory function of DNT cells.
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Also filed as BioProject PRJNA1207974 and SRA study SRP556123. Searching any of these in the dataset finder brings you back here.

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