BRAF inhibition increases TGFb2 production and stimulates metastasis in mice with endogenous BRAFV600E-induced hepatocellular carcinoma
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- BRAF inhibition increases TGFβ2 production and stimulates metastasis in mice with endogenous BRAF(V600E)-induced hepatocellular carcinomaProceedings of the National Academy of Sciences of the United States of America · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286241_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1208463 and SRA study SRP556329. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8721519 Primary Tumor_T1_DMSO
- GSM8721520 Primary Tumor_T1_PLX
- GSM8721521 Primary Tumor_T2_DMSO
- GSM8721522 Primary Tumor_T2_PLX
- GSM8721523 Primary Tumor_T3_DMSO
- GSM8721524 Primary Tumor_T3_PLX
- GSM8721525 Metastasis_M1_DMSO
- GSM8721526 Metastasis_M1_PLX
- GSM8721527 Metastasis_M2_DMSO
- GSM8721528 Metastasis_M2_PLX
- GSM8721529 Metastasis_M3_DMSO
- GSM8721530 Metastasis_M3_PLX
- GSE269008 Synthetic RIG-I agonist-mediated cancer immunotherapy synergizes with MAP-Kinase inhibition against BRAF mutated melanoma [YUMM1.7] 15 samples shares braf, inhibition
- GSE300751 CDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [liver tumor] 14 samples shares hepatocellular, inhibition
- GSE301906 Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma 10 samples shares hepatocellular, inhibition
- GSE279468 Gene expression profile at single cell level of Braf-mutant mouse melanoma tumor and skin 53 samples shares braf
- GSE296998 Novel syngeneic cell lines for studying high-risk BRAFV600E-driven colorectal cancer in vivo [RNA-seq_NaJa] 34 samples shares braf
- GSE227189 Single cell transcriptomic analyses of the dynamic local and systemic response to cardiac injury in mice and zebrafish [mouse] 28 samples shares braf
- GSE296999 Novel syngeneic cell lines for studying high-risk BRAFV600E-driven colorectal cancer in vivo [RNA-seq_organoids] 28 samples shares braf
- GSE306906 Fosl1 is a transcriptional effector of BRAFV600E-driven intestinal tumorigenesis 27 samples shares braf
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.