Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × aPD1_lef vs 4 × aPD1_veh vs 4 × IgG_lefGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in miceNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286252_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1208476 and SRA study SRP556285. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8721693 aPD1_lef_1 aPD1_lef
- GSM8721694 aPD1_lef_2 aPD1_lef
- GSM8721695 aPD1_lef_3 aPD1_lef
- GSM8721696 aPD1_lef_4 aPD1_lef
- GSM8721697 aPD1_veh_1 aPD1_veh
- GSM8721698 aPD1_veh_2 aPD1_veh
- GSM8721699 aPD1_veh_3 aPD1_veh
- GSM8721700 aPD1_veh_4 aPD1_veh
- GSM8721701 IgG_lef_1 IgG_lef
- GSM8721702 IgG_lef_2 IgG_lef
- GSM8721703 IgG_lef_3 IgG_lef
- GSM8721704 IgG_lef_4 IgG_lef
- GSE307421 Activation of CISD2 as a Protective Strategy against Doxorubicin-Induced Cardiotoxicity 24 samples shares cardiotoxicity, against
- GSE313129 Mitochondrial superoxide-mediated mitohormesis protects against doxorubicin-induced cardiotoxicity [AcuteDoxo_RNAseq] 12 samples shares cardiotoxicity, against
- GSE313130 Mitochondrial superoxide-mediated mitohormesis protects against doxorubicin-induced cardiotoxicity [6Week_RNAseq] 10 samples shares cardiotoxicity, against
- GSE327921 Targeting PDE2A of macrophages attenuates sorafenib-induced cardiotoxicity 12 samples shares cardiotoxicity
- GSE308615 p38 delta systemic genetic deletion mitigates anthracycline cardiotoxicity in female mice 10 samples shares cardiotoxicity
- GSE328472 Cancer Therapeutic TKI Osimertinib-induced Cardiotoxicity Is Driven by HDAC-Dependent Epigenetic Repression and Rescued by Vorinostat 10 samples shares cardiotoxicity
- GSE330352 Panax notoginseng -derived extracellular vesicles alleviate doxorubicin-induced cardiotoxicity by suppressing p53 activation 9 samples shares cardiotoxicity
- GSE233805 Oxaliplatin-induced cardiotoxicity in mice is connected to the changes in energy metabolism in the heart tissue 9 samples shares cardiotoxicity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.