GEO series
Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
GSE286252
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/02/01
GPL28330
Summary
Anti-programmed death 1 (αPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular toxicity. Finding drugs that suppress cardiovascular toxicity but not compromise the efficacy of αPD1-mediated immunotherapy is of great importance. Leflunomide (Lef) can suppress the growth of several tumor and mitigate cardiac remodeling in mice. However, the specific role of Lef in αPD1-induced cardiotoxicity remains unclear.
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Paper (PMID 40108157) ↗
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