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Comparision of PBMC from PTEN loss and WT glioblastoma patients

GSE286354 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/01/01 Platform GPL11154
Summary
Glioblastoma (GBM) is a lethal type of brain tumor that is resistant to immunotherapy. Genetic profiling studies have indicated that the tumorigenesis of GBM is linked to somatic genomic alterations in key driver genes, such as TP53, PTEN, CDKN2A, RB1, EGFR, and NF1. These genes regulate critical pathways related to cell growth and resistance to immunotherapy, including the use of immune checkpoint inhibitors (ICIs). One reason for resistance to ICI therapy may be the presence of immunosuppressive myeloid cells, including macrophages and myeloid-derived suppressor cells (MDSCs). We conducted an unbiased analysis to identify specific genetic alterations in GBM cells that may influence MDSC biology and contribute to resistance against immunotherapy.
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Direct links to NCBI, no account and no request form: the whole study as GSE286354_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1208962 and SRA study SRP556512. Searching any of these in the dataset finder brings you back here.

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