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Liver TET1 promotes metabolic dysfunction-associated steatotic liver disease

GSE286394 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/03/04 Platform GPL21103
Summary
DNA demethylation is regulated by the TET family proteins, whose enzymatic activity requires 2-oxoglutarate (2-OG) and iron that both are elevated in MASLD. We aimed to investigate liver TET1 in MASLD progression. Depleting TET1 substantially alleviated MASLD progression. Whole body Knockout of TET1 (TKO) slightly improved diet induced obesity and glucose homeostasis. Intriguingly, hepatic cholesterols, triglycerides, were significantly decreased upon TET1 depletion. Moreover, targeting TET1 with a small molecule inhibitor significantly suppressed MASLD progression. Liver TET1 plays a deleterious role in MASLD, suggesting the potential of targeting TET1 in hepatocytes to suppress MASLD.
Published in
Liver TET1 promotes metabolic dysfunction-associated steatotic liver disease
Chen H, Nisar MA, Mulla J et al. · EMBO molecular medicine 2025 · PMID 40164757 · doi:10.1038/s44321-025-00224-4
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Also filed as BioProject PRJNA1209064 and SRA study SRP556529. Searching any of these in the dataset finder brings you back here.

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