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Brain-wide mapping of immune receptors uncovers a neuro-modulatory role of interleukin-17E and the receptor IL-17RB.

GSE286801 Mus musculus (mouse) RNA-seq (gene expression) 10 samples Submitted 2025/04/07 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 10 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
10 samples: 4 × Il-17rc vs 3 × Il-17ra vs 3 × Il-17rbGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RBCell · 2025
Summary (written by the submitters)
Cytokines engage with their receptor complexes to orchestrate diverse processes -- from immune responses to modulating behaviors. Interleukin-17A (IL-17A) mediates protective immune responses by binding to IL-17 receptor A (IL-17A) and IL-17RC subunits. IL-17A also modulates social interaction, but the role of cytokine receptors in this process and their expression in the brain is not well characterized.
Read the full summary ↓
Here, we mapped the brain-region-specific expression of all major IL-17R subunits and discovered that IL-17RB, not IL-17RC, expression in the cortex plays a role in social behaviors. Through genetic experiments, we further showed that IL-17E, a ligand for the IL-17RB-containing receptor complex, enhances social interaction by directly impacting IL-17RB-expressing neurons in the cortex. These findings highlight a novel IL-17 circuit operating within the cortex to modulate social behaviors. Thus, characterizing spatially restricted cytokine receptor expression can be leveraged to elucidate how cytokines function as critical messengers mediating neuro-immune interactions to shape animal behaviors.
Published in
Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB
Lee Y, Ishikawa T, Lee H et al. · Cell 2025 · PMID 40199322 · doi:10.1016/j.cell.2025.03.006
This dataset
Open GSE286801 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286801_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1209991 and SRA study SRP557089. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40199322) ↗
Study design
4 × Il-17rc vs 3 × Il-17ra vs 3 × Il-17rb

Supports a between-group comparison across 10 samples.

How we read this: 3 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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