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Impact of Fibrin Networks Formed by Macroporous Hydrogels with Varied Protein Absorption Capacities on Macrophage Function

GSE286900 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/14 Platform GPL9185
Summary
Over the last decade, several materials strategies - such as anti-fouling hydrogels, surface coatings, and alterations in physical properties have been developed to reduce FBR by minimizing fibrotic encapsulation, though it remains inevitable. To investigate the mechanisms by which the early formation structure of host proteins (i.e. fibrin network) affects macrophage function. We developed a model system to investigate the effects of different fibrin network structures on macrophages by modifying sodium methacrylate alginate with zwitterionic (sulfobetaine) or dopamine (hereafter MSA-ZW/MSA-DA). Our data elucidated alterations in macrophage gene expression, offering insights into the potential mechanisms by which fibrin network structures influence macrophage biological processes.
Published in
Macrophage response to fibrin structure mediated by Tgm2-dependent mitochondrial mechanosensing
Gao B, Ni H, Lai J et al. · Bioactive materials 2025 · PMID 40331213 · doi:10.1016/j.bioactmat.2025.04.022
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Also filed as BioProject PRJNA1210520 and SRA study SRP557229. Searching any of these in the dataset finder brings you back here.

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