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CNOT7 Promotes Radiation Resistance in Colorectal Cancer via XRCC6-Mediated NHEJ DNA Repair Pathway

GSE287014 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/28 Platform GPL24676
Summary
In this study, we identified CNOT7 as a key protein influencing the radiotherapy sensitivity of rectal cancer through proteomic sequencing of patient tissues. Patients with high CNOT7 expression often exhibit poorer prognoses during radiotherapy. We explored the potential mechanisms by which CNOT7 affects radiotherapy sensitivity in CRC. CNOT7 reduces polyubiquitination of K48 linked lysine 526 on XRCC6 by regulating TRIM21. This enhances DNA damage repair primarily mediated by the NHEJ pathway, thereby conferring radiotherapy resistance to colorectal cancer cells. Our study suggests that targeting CNOT7 could serve as a potential therapeutic strategy for rectal cancer patients
Published in
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair
Li Y, Cui L, Wang S et al. · Cell death & disease 2025 · PMID 41249119 · doi:10.1038/s41419-025-08160-4
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Also filed as BioProject PRJNA1210974 and SRA study SRP557411. Searching any of these in the dataset finder brings you back here.

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