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Gene expression analysis of hepatocyte-specific Taf2 conditional knockout mice

GSE287050 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/12 Platform GPL21493
Summary
Taf2 is a transcription co-factor and a member of TFIID complex. To better understand gene regulation of Taf2 we generated a hepatocyte-specific Taf2 conditional knockout mouse. RNA-seq was performed in hepatocytes isolated from these mice as well as WT mice. It shows that Taf2 deletion in hepatocytes induces cell death and compensatory proliferation which contributes to inflammation and fibrosis in the liver.
Published in
TATA-box binding protein-associated factor 2 (TAF2) in hepatocyte survival and tumorigenesis
Reghupaty SC, Raha S, Mendoza R et al. · Hepatology (Baltimore, Md.) 2026 · PMID 40392063 · doi:10.1097/HEP.0000000000001406
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Also filed as BioProject PRJNA1211062 and SRA study SRP557698. Searching any of these in the dataset finder brings you back here.

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