Comparative Transcriptomic Analysis of Embryonic Hearts in Atf4 Exon 2 and Exon 2–3 Conditional Knockout Mice
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × RNA-seq of Atf4 exon2-3 Control mice E11.5 heart vs 4 × RNA-seq of Atf4 exon2-3 cKO mice E11.5 heart vs 4 × RNA-seq of Atf4 exon2 Control mice E11.5 heart vs 4 × RNA-seq of Atf4 exon2 cKO mice E11.5 heartGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcriptional readthrough at Atf4 locus suppresses Rps19bp1 and impairs heart developmentCardiovascular research · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE303929_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1298246 and SRA study SRP604415. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9138310 RNA-seq of Atf4 exon2-3 Control mice E11.5 heart replicate 1 RNA-seq of Atf4 exon2-3…
- GSM9138311 RNA-seq of Atf4 exon2-3 Control mice E11.5 heart replicate 2 RNA-seq of Atf4 exon2-3…
- GSM9138312 RNA-seq of Atf4 exon2-3 Control mice E11.5 heart replicate 3 RNA-seq of Atf4 exon2-3…
- GSM9138313 RNA-seq of Atf4 exon2-3 Control mice E11.5 heart replicate 4 RNA-seq of Atf4 exon2-3…
- GSM9138314 RNA-seq of Atf4 exon2-3 cKO mice E11.5 heart replicate 1 RNA-seq of Atf4 exon2-3…
- GSM9138315 RNA-seq of Atf4 exon2-3 cKO mice E11.5 heart replicate 2 RNA-seq of Atf4 exon2-3…
- GSM9138316 RNA-seq of Atf4 exon2-3 cKO mice E11.5 heart replicate 3 RNA-seq of Atf4 exon2-3…
- GSM9138317 RNA-seq of Atf4 exon2-3 cKO mice E11.5 heart replicate 4 RNA-seq of Atf4 exon2-3…
- GSM9138318 RNA-seq of Atf4 exon2 Control mice E11.5 heart replicate 1 RNA-seq of Atf4 exon2 C…
- GSM9138319 RNA-seq of Atf4 exon2 Control mice E11.5 heart replicate 2 RNA-seq of Atf4 exon2 C…
- GSM9138320 RNA-seq of Atf4 exon2 Control mice E11.5 heart replicate 3 RNA-seq of Atf4 exon2 C…
- GSM9138321 RNA-seq of Atf4 exon2 Control mice E11.5 heart replicate 4 RNA-seq of Atf4 exon2 C…
- GSM9138322 RNA-seq of Atf4 exon2 cKO mice E11.5 heart replicate 1 RNA-seq of Atf4 exon2 c…
- GSM9138323 RNA-seq of Atf4 exon2 cKO mice E11.5 heart replicate 2 RNA-seq of Atf4 exon2 c…
- GSM9138324 RNA-seq of Atf4 exon2 cKO mice E11.5 heart replicate 3 RNA-seq of Atf4 exon2 c…
- GSM9138325 RNA-seq of Atf4 exon2 cKO mice E11.5 heart replicate 4 RNA-seq of Atf4 exon2 c…
- GSE232845 Effect of conditional triple-knockout of Jmjd2a/Kdm4a, Jmjd2b/Kdm4b and Jmjd2c/Kdm4c or overexpression of KDM4C/JMJD2C mutants with different phase separation ability on gene expression in mouse embryonic stem cells. [ChIP-Seq] 46 samples shares conditional, embryonic, knockout
- GSE336472 Knockdown and knockout of the Integrated Stress Response (ISR) and ATF4 in cultures of adult mouse dorsal root ganglia 28 samples shares atf4, knockout
- GSE229815 Transcriptional profiling of 12 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 heterozygous or homozygous conditional knockout mice [Msh2_12mon] 138 samples shares conditional, knockout
- GSE229817 Transcriptional profiling of 6 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 conditional knockout mice [Msh2_6mon] 64 samples shares conditional, knockout
- GSE284404 Increased cardiac macrophages in Sorbs2-deficient hearts: revealing a potential role for macrophage in responding to embryonic myocardial abnormalities 35 samples shares embryonic, hearts
- GSE205029 Single Cell Sequencing Data of Mouse Spinal Cord with Dorsal Column Lesion and Astrocyte-Specific Ryk conditional Knockout 16 samples shares conditional, knockout
- GSE301313 Transcriptional differences in jejunum and ileum of a conditional knockout of Dab2 in the intestine 12 samples shares conditional, knockout
- GSE288210 Comparative gene expression profiling of RNA-seq data from islets of β-cell-specific ZZEF1 knockout mice (βZKO-Mip) and their littermate controls, treated with either azoramide or DMSO. 11 samples shares comparative, knockout
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.