Epigenetic de-repression of drivers of neuroendocrine prostate cancer [CUT&Run]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 30 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 30 samples: 15 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer ProgressionCancer research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287182_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1211567 and SRA study SRP557908. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 30 samples.
How we read this: 15 replicated groups read from 30 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8740582 WCM154_H3K27ac_rep1 WCM154_H3K27ac
- GSM8740583 WCM154_H3K27ac_rep2 WCM154_H3K27ac
- GSM8740584 WCM155_IgG_rep1 WCM155_IgG
- GSM8740585 WCM155_IgG_rep2 WCM155_IgG
- GSM8740586 WCM155_H3K4me3_rep1 WCM155_H3K4me3
- GSM8740587 WCM155_H3K4me3_rep2 WCM155_H3K4me3
- GSM8740588 WCM155_H3K27me3_rep1 WCM155_H3K27me3
- GSM8740589 WCM155_H3K27me3_rep2 WCM155_H3K27me3
- GSM8740590 WCM155_H3K27ac_rep1 WCM155_H3K27ac
- GSM8740591 WCM155_H3K27ac_rep2 WCM155_H3K27ac
- GSM8740592 WCM1078_IgG_rep1 WCM1078_IgG
- GSM8740593 WCM1078_IgG_rep2 WCM1078_IgG
- GSM8740594 WCM1078_H3K4me3_rep1 WCM1078_H3K4me3
- GSM8740595 WCM1078_H3K4me3_rep2 WCM1078_H3K4me3
- GSM8740596 WCM1078_H3K27me3_rep1 WCM1078_H3K27me3
- GSM8740597 WCM1078_H3K27me3_rep2 WCM1078_H3K27me3
- GSM8740598 WCM1078_H3K27ac_rep1 WCM1078_H3K27ac
- GSM8740599 WCM1078_H3K27ac_rep2 WCM1078_H3K27ac
- GSM8740600 WCM1262_IgG_rep1 WCM1262_IgG
- GSM8740601 WCM1262_IgG_rep2 WCM1262_IgG
- GSM8740602 WCM1262_H3K4me3_rep1 WCM1262_H3K4me3
- GSM8740603 WCM1262_H3K4me3_rep2 WCM1262_H3K4me3
- GSM8740604 WCM1262_H3K27me3_rep1 WCM1262_H3K27me3
- GSM8740605 WCM1262_H3K27me3_rep2 WCM1262_H3K27me3
- GSM8740606 WCM1262_H3K27ac_rep1 WCM1262_H3K27ac
- GSM8740607 WCM1262_H3K27ac_rep2 WCM1262_H3K27ac
- GSM8740608 WCM154_IgG_rep1 WCM154_IgG
- GSM8740609 WCM154_IgG_rep2 WCM154_IgG
- GSM8740610 WCM154_PROX1_rep1 WCM154_PROX1
- GSM8740611 WCM154_PROX1_rep2 WCM154_PROX1
- GSE339365 Genome-wide H3K4me3 profiling of circulating immune cells reveals dynamic epigenetic reprogramming during acute critical COVID-19 120 samples shares cut, epigenetic
- GSE315216 Lysine Pyruvylation Mediated by HAT1/p300-SIRT3 Couples Glycolytic Flux to Epigenetic Regulation [CUT&Tag] 12 samples shares cut, epigenetic
- GSE270503 Epigenetic heterogeneity and state-specific transcriptional programs determine differential drug response in osteosarcoma [Cut&Run] 56 samples shares cut, epigenetic
- GSE277275 Multi-omics Sequencing reveals Epigenetic Regulation in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma [m6A-seq] 40 samples shares cut, epigenetic
- GSE249080 Epigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia 40 samples shares cut, epigenetic
- GSE277273 Multi-omics Sequencing reveals Epigenetic Regulation in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma [850K DNA methylation array] 20 samples shares cut, epigenetic
- GSE295392 PIKfyve-regulated lipid metabolism as a therapeutic vulnerability in neuroendocrine prostate cancer 82 samples shares neuroendocrine, prostate
- GSE291224 AF9/KLF2 gene regulatory circuit links histone lactylation to breast cancer metastasis [CUT&Tag] 22 samples shares cut
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.