Epigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 40 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Acute myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 40 samples: 14 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemiaBlood · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249080_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1047121 and SRA study SRP475183. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 28 samples.
How we read this: 14 replicated groups read from 40 sample titles; they account for 28 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7926035 AML2_sgLuc_DMSO_H2AK119ub
- GSM7926036 AML2_sgLuc_DMSO_Menin
- GSM7926037 AML2_sgLuc_VTP50469_H2AK119ub
- GSM7926038 AML2_sgLuc_VTP50469_Menin
- GSM7926039 AML2_sgPCGF1_DMSO_H2AK119ub
- GSM7926040 AML2_sgPCGF1_DMSO_Menin
- GSM7926041 AML2_sgPCGF1_VTP50469_H2AK119ub
- GSM7926042 AML2_sgPCGF1_VTP50469_Menin
- GSM7926043 Input_AML2_sgLuc_DMSO
- GSM7926044 Input_AML2_sgLuc_VTP50469
- GSM7926045 Input_AML2_sgPCGF1_DMSO
- GSM7926046 Input_AML2_sgPCGF1_VTP50469
- GSM7926052 AML2_sgLuc_DMSO_control_Rep1 AML2_sgLuc_DMSO_control
- GSM7926053 AML2_sgLuc_DMSO_control_Rep2 AML2_sgLuc_DMSO_control
- GSM7926054 AML2_sgLuc_VTP50469_Rep1 AML2_sgLuc_VTP50469
- GSM7926055 AML2_sgLuc_VTP50469_Rep2 AML2_sgLuc_VTP50469
- GSM7926056 AML2_sgPCGF1_8_DMSO_Rep1 AML2_sgPCGF1_8_DMSO
- GSM7926057 AML2_sgPCGF1_8_DMSO_Rep2 AML2_sgPCGF1_8_DMSO
- GSM7926058 AML2_sgPCGF1_8_VTP50469_Rep1 AML2_sgPCGF1_8_VTP50469
- GSM7926059 AML2_sgPCGF1_8_VTP50469_Rep2 AML2_sgPCGF1_8_VTP50469
- GSM7926060 AML2_sgBCOR_7_DMSO_Rep1 AML2_sgBCOR_7_DMSO
- GSM7926061 AML2_sgBCOR_7_DMSO_Rep2 AML2_sgBCOR_7_DMSO
- GSM7926062 AML2_sgBCOR_7_VTP50469_Rep1 AML2_sgBCOR_7_VTP50469
- GSM7926063 AML2_sgBCOR_7_VTP50469_Rep2 AML2_sgBCOR_7_VTP50469
- GSM7926064 MV411_sgLuc_DMSO_Rep1 MV411_sgLuc_DMSO
- GSM7926065 MV411_sgLuc_DMSO_Rep2 MV411_sgLuc_DMSO
- GSM7926066 MV411_sgLuc_VTP50469_Rep1 MV411_sgLuc_VTP50469
- GSM7926067 MV411_sgLuc_VTP50469_Rep2 MV411_sgLuc_VTP50469
- GSM7926068 MV411_sgPCGF1_8_DMSO_Rep1 MV411_sgPCGF1_8_DMSO
- GSM7926069 MV411_sgPCGF1_8_DMSO_Rep2 MV411_sgPCGF1_8_DMSO
- GSM7926070 MV411_sgPCGF1_8_VTP50469_Rep1 MV411_sgPCGF1_8_VTP50469
- GSM7926071 MV411_sgPCGF1_8_VTP50469_Rep2 MV411_sgPCGF1_8_VTP50469
- GSM7926072 MOLM13_sgLuc_DMSO_Rep1 MOLM13_sgLuc_DMSO
- GSM7926073 MOLM13_sgLuc_DMSO_Rep2 MOLM13_sgLuc_DMSO
- GSM7926074 MOLM13_sgLuc_VTP50469_Rep1 MOLM13_sgLuc_VTP50469
- GSM7926075 MOLM13_sgLuc_VTP50469_Rep2 MOLM13_sgLuc_VTP50469
- GSM7926076 MOLM13_sgPCGF1_8_DMSO_Rep1 MOLM13_sgPCGF1_8_DMSO
- GSM7926077 MOLM13_sgPCGF1_8_DMSO_Rep2 MOLM13_sgPCGF1_8_DMSO
- GSM7926078 MOLM13_sgPCGF1_8_VTP50469_Rep1 MOLM13_sgPCGF1_8_VTP504…
- GSM7926079 MOLM13_sgPCGF1_8_VTP50469_Rep2 MOLM13_sgPCGF1_8_VTP504…
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.