RSK1-driven TRIM28-E2F1 feedback loop promotes castration-resistant prostate cancer progression
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 15 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Prostate cancerThis series is part of our curated briefing on it.
- Samples
- 15 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progressionThe Journal of clinical investigation · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287229_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1211646 and SRA study SRP557901. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 15 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8741842 LN LKO E2F1 rep1 LN LKO E2F1
- GSM8741843 LN LKO E2F1 rep2 LN LKO E2F1
- GSM8741844 LN shTRIM28 E2F1 rep1 LN shTRIM28 E2F1
- GSM8741845 LN shTRIM28 E2F1 rep2 LN shTRIM28 E2F1
- GSM8741846 LN shRb E2F1 rep1 LN shRb E2F1
- GSM8741847 LN shRb E2F1 rep2 LN shRb E2F1
- GSM8741848 LN shRb shTRIM28 E2F1 rep1 LN shRb shTRIM28 E2F1
- GSM8741849 LN shRb shTRIM28 E2F1rep 2 LN shRb shTRIM28 E2F1
- GSM8741850 TRIM28 LKO CR ad 26
- GSM8741851 TRIM28 WT rep2
- GSM8741852 TRIM28 473A rep2
- GSM8741853 WT ATAC ad 2.1 WT ATAC ad 2
- GSM8741854 WT ATAC ad 2.2 WT ATAC ad 2
- GSM8741855 473A ATAC ad 2.5 473A ATAC ad 2
- GSM8741856 473A ATAC ad 2.6 473A ATAC ad 2
- GSE115501 RNA sequencing on circulating tumor cells from prostate cancer patients 136 samples same disease briefing · shares prostate
- GSE222467 The RNA binding proteins LARP4A and LARP4B promote tumour growth and metastasis in prostate cancer and osteosarcoma 12 samples same disease briefing · shares prostate
- GSE300947 A novel six-biomarker panel identified from male breast cancer-associated fibroblasts demonstrates prognostic power for prostate tumors 6 samples same disease briefing · shares prostate
- GSE120181 Human prostate cancer cell line, 22Rv1: Control vs. luteolin treatment 2 samples same disease briefing · shares prostate
- GSE71008 Plasma extracellular RNA profiles in healthy and cancer patients 192 samples same disease briefing
- GSE242541 ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity 12 samples same disease briefing
- GSE268252 USP11 promotes prostate cancer progression by upregulating AR and c-Myc activity [CUT&RUN] 26 samples shares progression, promotes, prostate
- GSE316851 SETDB1-mediated repression of RhoB promotes EMT and metastatic progression in prostate cancer [RNA-Seq] 9 samples shares progression, promotes, prostate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.