Single-cell RNA-sequencing of HNSCC-infiltrating T cells

This study examines the T cell landscape in head and neck squamous cell carcinoma (HNSCC) using single-cell RNA sequencing combined with T cell receptor and protein profiling. By analyzing tumor-infiltrating T cells from 28 patients, we identified diverse T cell subsets, characterized their transcriptional states, and mapped their clonal dynamics. These findings provide a detailed view of the immune microenvironment in HNSCC and offer insights into T cell-mediated immunity and potential targets for immunotherapy and are patient-matched to PBMC TCR sequencing and Xenium spatial transcriptomics in separate GEO submissions.