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Antcin K inhibits chondrosarcoma motility by reducing MMP-7 expression via down-regulating PI3K, Akt, mTOR and NF-κB signaling pathway

GSE287361 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/01/18 Platform GPL24676
Summary
Chondrosarcoma is recognized as the second most common form of primary bone cancer originating from cartilage. Antrodia cinnamomea is the source of the triterpenoid Antcin K, renowned for its immunomodulatory and anti-inflammatory properties. However, the therapeutic function of Antcin K on chondrosarcoma remains unclear. Our investigation found that Antcin K reduces migration and invasion in two chondrosarcoma cell lines. Finally, our study provided evidence of Antcin K as a novel candidate for inhibiting chondrosarcoma motility by inhibiting MMP-7 expression through suppressing the PI3K, Akt, mTOR, and NF-κB signaling cascades.
Published in
Antcin K inhibits chondrosarcoma motility by reducing MMP‑7 expression via downregulation of the PI3K, Akt, mTOR and NF‑κB signaling pathway
Law YY, Tran NB, Song CY et al. · Molecular medicine reports 2025 · PMID 40280107 · doi:10.3892/mmr.2025.13545
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Also filed as BioProject PRJNA1212214 and SRA study SRP558148. Searching any of these in the dataset finder brings you back here.

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