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Dysfunctional b-cell autophagy induces b-cell stress and enhances islet immunogenicity

GSE287583 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/21 Platform GPL24247
Summary
We knocked out the critical autophagy enzyme, ATG7, in the β-cells of mice (ATG7Δβ-cell) then monitored blood glucose to assess the phenotype induced by this KO model. We found that all ATG7Δβ-cell mice developed diabetes between 11-15 weeks of age. We isolated islets from ATG7Δβ-cell and littermate control mice several weeks prior to diabetes development (7-10 weeks of age) and performed bulk islet mRNA sequencing. The purpose of this experiment was to understand the islet biological process pathways altered by dysfunctional β-cell autophagy in the ATG7Δβ-cell model.
Published in
Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity
Austin MC, Muralidharan C, Roy S et al. · Frontiers in immunology 2025 · PMID 39944686 · doi:10.3389/fimmu.2025.1504583
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Also filed as BioProject PRJNA1213782 and SRA study SRP558789. Searching any of these in the dataset finder brings you back here.

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