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Role of ACK1 condensates in STAT5 activation in LUSC cells

GSE287607 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/02 Platform GPL29480
Summary
ACK1 is a non-receptor tyrosine kinase that phosphorylates multiple substrates involved in cancer progression. Additional regulatory mechanisms governing ACK1 activity remain to be elucidated. We demonstrate that ACK1 is frequently amplified and overexpressed in lung squamous cell carcinoma (LUSC). We found that ACK1 undergoes liquid-liquid phase separation (LLPS), a process dependent on the intrinsically disordered region (IDR, 96-156aa), but independent of its kinase activity. Our data also reveal that ACK1 phosphorylates STAT5 and promote STAT5 nuclear localization and transcriptional activity.
Published in
ACK1 condensates promote STAT5 signaling in lung squamous cell carcinoma
Liu A, Lu X, Song Y et al. · Cancer cell international 2025 · PMID 40581662 · doi:10.1186/s12935-025-03862-3
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Also filed as BioProject PRJNA1213808 and SRA study SRP558794. Searching any of these in the dataset finder brings you back here.

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