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Mettl3 regulates lens development by promoting the differentiation processes of secondary fiber cells [RNA-seq]

GSE287640 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/07/23 Platform GPL24247
Summary
Lens development requires tight regulation of cell proliferation and differentiation processes, the disruption of which leads to congenital cataract formation. N6-methyladenosine (m6A) is the most prevalent internal mRNA internal modification and has been shown to play important roles in regulating the development, physiology and pathology of various organs and tissues. However, the function of m6A during lens development remains unknown. In this study, we used lens-specific Mettl3 conditional knockout mice as a model to study the function of Mettl3 during lens development. Our study revealed that Mettl3 plays essential role in lens development by promoting the differentiation processes of secondary fiber cells.
Published in
Mettl3 Regulates Lens Development by Promoting the Differentiation Processes of Secondary Fiber Cells
Hu L, Ma J, Guo J et al. · Investigative ophthalmology & visual science 2025 · PMID 40662889 · doi:10.1167/iovs.66.9.45
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Also filed as BioProject PRJNA1213886 and SRA study SRP558911. Searching any of these in the dataset finder brings you back here.

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