GEO series
The influence of the geroprotective cytokine on the transcriptome of young and old mesenchymal stem cells
GSE287646
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2025/04/30
GPL24676
Summary
Increasing longevity and the growing elderly population necessitate a deeper understanding of aging mechanisms to prolong productive life and improve treatments for age-related diseases linked with cellular senescence. Mesenchymal stem cells (MSCs) are crucial for maintaining tissue homeostasis, but their physiological changes during senescence are not well understood. Growth differentiation factor 11 (GDF11) has emerged as a potential rejuvenation factor, enhancing MSC viability, mobility, and angiogenic functions, which improves outcomes in ischemic models and cardiac repair. This study aims to identify transcriptomic changes in young and senescent MSCs influenced by GDF11, highlighting its potential in MSC-based therapies.
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Paper (PMID 40275319) ↗
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