Effect of aging on gene expression in the skeletal muscle
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287832_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1214791 and SRA study SRP559537. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8752128 EDL_Old_1 EDL_Old
- GSM8752130 EDL_Old_2 EDL_Old
- GSM8752132 EDL_Old_3 EDL_Old
- GSM8752133 EDL_Young_1 EDL_Young
- GSM8752135 EDL_Young_2 EDL_Young
- GSM8752137 EDL_Young_3 EDL_Young
- GSM8752139 Soleus_Old_1 Soleus_Old
- GSM8752141 Soleus_Old_2 Soleus_Old
- GSM8752142 Soleus_Old_3 Soleus_Old
- GSM8752144 Soleus_Young_1 Soleus_Young
- GSM8752146 Soleus_Young_2 Soleus_Young
- GSM8752148 Soleus_Young_3 Soleus_Young
- GSM8752149 TA_Old_1 TA_Old
- GSM8752151 TA_Old_2 TA_Old
- GSM8752153 TA_Old_3 TA_Old
- GSM8752155 TA_Young_1 TA_Young
- GSM8752156 TA_Young_2 TA_Young
- GSM8752158 TA_Young_3 TA_Young
- GSE268407 Cellular senescence in skeletal muscle aging: new mechanisms and therapeutic potential for sarcopenia 2 samples shares skeletal, muscle, aging
- GSE186648 Skeletal muscle mRNA expression in 25 mice with or without genetic defects of mitochondrial fatty acid oxidation (Acadl and Acadvl knockout) using RNA sequencing. 25 samples shares skeletal, muscle
- GSE267727 Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, heart, and skeletal muscle tissue from mice fed high-fat, high-sugar diet [heart] 482 samples shares skeletal, muscle
- GSE266918 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [heart] 63 samples shares skeletal, muscle
- GSE266923 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [liver] 61 samples shares skeletal, muscle
- GSE297515 Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging 90 samples shares muscle, aging
- GSE329069 Deletion of P311 enhances regeneration in aged skeletal muscle 9 samples shares skeletal, muscle
- GSE253735 Loss of skeletal muscle Bmal1 +/- Exercise Training [Mouse liver, heart, inguinal white adipose and lung tissues 64 samples shares skeletal, muscle
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.