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Androgen regulated ECD overexpression promotes prostate cancer tumorigenesis through increased glycolysis

GSE287898 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/02 Platform GPL24676
Summary
Prostate cancer (PC) is the second most common cancer in men worldwide. Androgen receptor (AR)-mediated signaling is essential for PC tumorigenesis and use of AR inhibitors is the first line of therapy until patients develop androgen-resistant PC. Here, we report that the mammalian orthologue of the drosophila ecdysoneless (ECD) mRNA and protein are overexpressed in PC patient tissues as compared to hyperplastic prostate tissues, and its overexpression predicts shorter survival in patients. RNA-seq analysis of mouse tumors revealed increase mRNA levels of several glycolytic genes in ECD-overexpressing tumors. Our results support a novel role of androgen regulated ECD overexpression in PC tumorigenesis through direct ECD binding and stabilization of mRNAs of key glycolytic genes.
Published in
ECD, a novel androgen receptor target promotes prostate cancer tumorigenesis by regulating glycolysis
Raza M, Rajan AR, Kennedy BB et al. · Oncogene 2025 · PMID 40908313 · doi:10.1038/s41388-025-03559-x
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Also filed as BioProject PRJNA1214886 and SRA study SRP559548. Searching any of these in the dataset finder brings you back here.

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