← BioTransfer GEO Dataset Finder
GEO series

Endometrial mesenchymal stem cell derived exosomal miR-4669 promotes EMT by inducing M2 macrophage polarization via the DUSP6/ERK pathway in adenomyosis

GSE287900 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/30 Platform GPL34284
Summary
Adenomyosis-associated macrophage (AAM) polarization-induced epithelial‐mesenchymal transition (EMT) has been implicated as a key driver in AM progression. Mechanistic studies revealed that miR-4669 induces M2 macrophage polarization by directly downregulating DUSP6 expression and activating the MAPK/ERK pathway. In turn, the polarized M2 macrophages promote EMT in ISK cells via TGF-β1 secretion. In vivo studies demonstrated that miR-4669 depletion inhibits EECs invasion and migration by targeting the DUSP6/ERK1/2 pathway in macrophages.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE287900_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1214918 and SRA study SRP559567. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.