EPHB2 Drives EMT-Linked Vasculogenic Mimicry and Cervical Cancer Progression via an ERK–ETV4 Transcriptional Program
RNA-seq (gene expression) · human · 9 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Cervical cancerThis series is part of our curated briefing on it.
- Samples
- 9 samples: 3 × HeLa_siCtrl vs 3 × HeLa_siEPHB2_si1 vs 3 × HeLa_siEPHB2_si2Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- EPHB2 drives EMT-linked vasculogenic mimicry and cervical cancer progression via an ERK-ETV4 transcriptional programJournal of translational medicine · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE326407_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1445209 and SRA study SRP687747. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 9 samples.
How we read this: 3 replicated groups read from 9 sample titles; they account for 9 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9630496 HeLa_siCtrl_rep1 HeLa_siCtrl
- GSM9630497 HeLa_siCtrl_rep2 HeLa_siCtrl
- GSM9630498 HeLa_siCtrl_rep3 HeLa_siCtrl
- GSM9630499 HeLa_siEPHB2_si1_rep1 HeLa_siEPHB2_si1
- GSM9630500 HeLa_siEPHB2_si1_rep2 HeLa_siEPHB2_si1
- GSM9630501 HeLa_siEPHB2_si1_rep3 HeLa_siEPHB2_si1
- GSM9630502 HeLa_siEPHB2_si2_rep1 HeLa_siEPHB2_si2
- GSM9630503 HeLa_siEPHB2_si2_rep2 HeLa_siEPHB2_si2
- GSM9630504 HeLa_siEPHB2_si2_rep3 HeLa_siEPHB2_si2
- GSE279412 Differentially Expressed Genes in C-33A and CaSki Cells Overexpressing miR-124-3p, miR-23b-3p, or miR-218-5p Modulate Processes and Pathways Involved in Cervical Cancer Progression 23 samples same disease briefing · shares progression, cervical
- GSE289927 Overexpression of miR-23b-3b+miR-218-5p+miR-124-3p differentially modifies the transcriptome of C-33A and CaSki cells and the regulation of cellular processes involved in the progression of cervical cancer 12 samples same disease briefing · shares progression, cervical
- GSE306495 Elevated VAMP8 Expression Promotes Cervical Cancer Progression by Enhancing Autophagy via HIF-1 Pathway 12 samples same disease briefing · shares progression, cervical
- GSE297095 ADAR1 expression is associated with cervical cancer progression and negatively regulates NK cell activity 8 samples same disease briefing · shares progression, cervical
- GSE316098 Spatial Transcriptomic Landscape of Invasion Patterns in Human Papillomavirus-Associated Endocervical Adenocarcinoma 186 samples same disease briefing · shares cervical
- GSE303300 Neoadjuvant Immune Checkpoint Blockade Before Chemoradiation for Patients with FIGO Stage IB3–IVA Cervical Squamous Carcinoma: GINECO Window-Of-Opportunity COLIBRI Study 96 samples same disease briefing · shares cervical
- GSE168244 Patient-derived organoids as a platform to study cervical cancer and viral infection 36 samples same disease briefing · shares cervical
- GSE299125 Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways 35 samples same disease briefing · shares cervical
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.