The combination of IL-7Ra and CCR7 is a highly specific marker to identify and purify homeostatically matured cDC2s (DC2hm).
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 14 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Homeostatic maturation programs drive human cDC2s into a tolerogenic stateImmunity · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287912_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1215268 and SRA study SRP559625. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 18 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8754350 Sorted cDCs, Dnr1_cDC1
- GSM8754351 Sorted cDCs, Dnr1_cDC2
- GSM8754352 Sorted cDCs, Dnr1_IL7R+CCR7-
- GSM8754353 Sorted cDCs, Dnr1_IL7R+CCR7+
- GSM8754354 Sorted cDCs, Dnr2_cDC1
- GSM8754355 Sorted cDCs, Dnr2_cDC2
- GSM8754356 Sorted cDCs, Dnr2_IL7R+CCR7-
- GSM8754357 Sorted cDCs, Dnr2_IL7R+CCR7+
- GSM8754358 Sorted cDCs, Dnr2_IL7R-CCR7+
- GSM8754359 Sorted cDCs, Dnr6_cDC1
- GSM8754360 Sorted cDCs, Dnr6_cDC2
- GSM8754361 Sorted cDCs, Dnr6_IL7R+CCR7-
- GSM8754362 Sorted cDCs, Dnr6_IL7R+CCR7+
- GSM8754363 Sorted cDCs, Dnr12_cDC1
- GSM8754364 Sorted cDCs, Dnr12_cDC2
- GSM8754365 Sorted cDCs, Dnr12_IL7R+CCR7-
- GSM8754366 Sorted cDCs, Dnr12_IL7R+CCR7+
- GSM8754367 Sorted cDCs, Dnr12_IL7R-CCR7+
- GSE272939 CCR7 Expression Distinguishes Functionally Distinct pTfh1 Subsets with Roles in Malaria-Specific Immunity 8 samples shares ccr7, specific
- GSE274397 Manifold roles of CCR7 chemokine GPCR in human trophoblast differentiation 28 samples shares ccr7
- GSE282671 STAT5 inhibition abrogate TSLP-induced homeostatic maturation of human cDC2s 6 samples shares cdc2s
- GSE275552 Manifold roles of CCR7 chemokine GPCR in human trophoblast differentiation 4 samples shares ccr7
- GSE49703 Transcriptional profiles of CCR7lo effector memory human T cell subsets 8 samples shares ccr7
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.