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Identified gene changes through RNA-sequencing following the knockdown of the COP1 gene in liver cancer

GSE287988 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/04/15 Platform GPL24676
Summary
COP1 is a ubiquitin E3 ligase that degrades the cancer suppressor gene p53. COP1 is overexpressed in human hepatocellular carcinoma, and there is evidence that knocking down COP1 can inhibit the growth of liver cancer. We hypothesized that COP1 may also be involved in the metabolism of liver cancer. To explore this, we treated human liver cancer cell lines Huh7 and HepG2 with COP1-siRNA and conducted RNA sequencing.
Published in
Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness
Jeon EH, Bae AN, Lee H et al. · Genes to cells : devoted to molecular & cellular mechanisms 2026 · PMID 41940593 · doi:10.1111/gtc.70108
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Also filed as BioProject PRJNA1215404 and SRA study SRP559717. Searching any of these in the dataset finder brings you back here.

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