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Thymic iNKT cells in Prkd2/3 mice (scRNA/TCR-seq, scATAC-seq)

GSE288015 Mus musculus Expression profiling by high throughput sequencing; Other 6 samples Submitted 2025/09/08 Platform GPL24247
Summary
We have conducted single cell-RNA, -TCR, -ATAC sequencing (10x Genomics) to investigate a difference of gene expression, TCR repertoir and chromatin accesibility of thymic iNKT cells from wild-type and CD4-Cre-mediated T cell-specific Prkd2/3 doubly deficirnt (Prkd2/3ΔCD4) mice. Results demonstrate that Prkd2/3 are required for iNKT cell development and formaion of proper iNKT cell subtypes.
Published in
Invariant TCR-triggered protein kinase D activation mediates NKT cell development
Ishikawa E, Kosako H, Motooka D et al. · The Journal of experimental medicine 2025 · PMID 40965511 · doi:10.1084/jem.20250541
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Also filed as BioProject PRJNA1215692 and SRA study SRP559853. Searching any of these in the dataset finder brings you back here.

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