Characterization of ALDH2-deficient alcohol-associated liver disease (duodenum RNA seq)
RNA-seq (gene expression) · mouse · 25 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 25 samples: 5 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Opposite regulation of intestinal and intrahepatic CD8(+) T cells controls alcohol-associated liver disease progressionGut · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288043_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1215761 and SRA study SRP559917. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 25 samples.
How we read this: 5 replicated groups read from 25 sample titles; they account for 25 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8757868 Duo_WT_Con1 Duo_WT_Con
- GSM8757869 Duo_WT_Con2 Duo_WT_Con
- GSM8757870 Duo_WT_Con3 Duo_WT_Con
- GSM8757871 Duo_WT_Con4 Duo_WT_Con
- GSM8757872 Duo_KI_Con1 Duo_KI_Con
- GSM8757873 Duo_KI_Con2 Duo_KI_Con
- GSM8757874 Duo_KI_Con3 Duo_KI_Con
- GSM8757875 Duo_KI_Con4 Duo_KI_Con
- GSM8757876 Duo_WT_Half1 Duo_WT_Half
- GSM8757877 Duo_WT_Half2 Duo_WT_Half
- GSM8757878 Duo_WT_Half3 Duo_WT_Half
- GSM8757879 Duo_WT_Half4 Duo_WT_Half
- GSM8757880 Duo_WT_Half5 Duo_WT_Half
- GSM8757881 Duo_WT_Half6 Duo_WT_Half
- GSM8757882 Duo_WT_Half7 Duo_WT_Half
- GSM8757883 Duo_KI_Half1 Duo_KI_Half
- GSM8757884 Duo_KI_Half2 Duo_KI_Half
- GSM8757885 Duo_KI_Half3 Duo_KI_Half
- GSM8757886 Duo_KI_Half5 Duo_KI_Half
- GSM8757887 Duo_KI_Half6 Duo_KI_Half
- GSM8757888 Duo_KI_Half7 Duo_KI_Half
- GSM8757889 Duo_WT_Full1 Duo_WT_Full
- GSM8757890 Duo_WT_Full2 Duo_WT_Full
- GSM8757891 Duo_WT_Full3 Duo_WT_Full
- GSM8757892 Duo_WT_Full4 Duo_WT_Full
- GSE244388 PCB126 Modifies the Murine Hepatic Transcriptome and Metallome to Promote Alcohol-associated Liver Disease Pathogenesis 24 samples shares alcohol-associated, liver
- GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples shares liver
- GSE310017 Disease-associated mutations on the STAT5B SH2 domain regulate cholesterol and lipid metabolism in liver [RNA-Seq liver] 37 samples shares liver
- GSE285614 Adipocyte death drives fat redistribution from adipocytes to hepatocytes in steatotic liver disease via S100A8+ macrophages [RNA-seq] 34 samples shares liver
- GSE318801 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease. 20 samples shares liver
- GSE294945 Mechanistic basis for protection against fatty liver disease by CIDEB loss-of-function mutations 20 samples shares liver
- GSE327752 Human breast milk-derived extracellular vesicles alleviate Alzheimer’s disease phenotypes through delivering CD36 18 samples shares liver
- GSE230838 Loss of cisPTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma [RNA-seq] 17 samples shares liver
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.