Metabolic dysfunction-associated steatotic liver disease may increase intrahepatic interferon gene signatures in patients with chronic hepatitis B
RNA-seq (gene expression) · human · 35 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 35 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Metabolic dysfunction-associated steatotic liver disease may increase intrahepatic interferon gene signatures in patients with chronic hepatitis BJournal of hepatology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288077_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1216006 and SRA study SRP560035. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 35 samples.
How we read this: 6 replicated groups read from 35 sample titles; they account for 35 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8758624 EM1 EM
- GSM8758625 EM2 EM
- GSM8758626 EM3 EM
- GSM8758627 EM4 EM
- GSM8758628 EM5 EM
- GSM8758629 EM6 EM
- GSM8758630 EM7 EM
- GSM8758631 EM8 EM
- GSM8758632 EM9 EM
- GSM8758633 EM10 EM
- GSM8758634 EM11 EM
- GSM8758635 E1 E
- GSM8758636 E2 E
- GSM8758637 E3 E
- GSM8758638 E4 E
- GSM8758639 E5 E
- GSM8758640 E6 E
- GSM8758641 E7 E
- GSM8758642 HBV1 HBV
- GSM8758643 HBV2 HBV
- GSM8758644 HBV3 HBV
- GSM8758645 HBV4 HBV
- GSM8758646 HBV5 HBV
- GSM8758647 HBV-MASLD1 HBV-MASLD
- GSM8758648 HBV-MASLD2 HBV-MASLD
- GSM8758649 HBV-MASLD3 HBV-MASLD
- GSM8758650 HBV-MASLD4 HBV-MASLD
- GSM8758651 Control1 Control
- GSM8758652 Control2 Control
- GSM8758653 Control3 Control
- GSM8758654 Control4 Control
- GSM8758655 MASLD1 MASLD
- GSM8758656 MASLD2 MASLD
- GSM8758657 MASLD3 MASLD
- GSM8758658 MASLD4 MASLD
- GSE288534 Targeting Senescent Hepatocytes for Treatment of Metabolic Dysfunction-associated Steatotic Liver Disease and Multi-organ Dysfunction 24 samples shares dysfunction-associated, steatotic
- GSE260966 Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators require high levels of intrahepatic HBV core protein 76 samples shares intrahepatic
- GSE271871 A leiomodin 2 neonatal dilated cardiomyopathy causing mutation results inaltered actin-regulatory gene signatures andcardiomyocyte dysfunction 42 samples shares signatures
- GSE307006 Interferon-γ mediated species-specific immune responses in macrophages to Mycobacterium tuberculosis 37 samples shares interferon
- GSE262137 Perfluorooctanesulfonic acid alters pro-cancer phenotypes and metabolic and transcriptional signatures in testicula germ cell tumors 26 samples shares signatures
- GSE97179 Single Cell Methylome Signatures Reveal Distinct Neuronal Populations and Regulatory Elements in the Mammalian Cortex 6172 samples shares signatures
- GSE270903 Hypoxic Memory Mediates Prolonged Tumor Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression 8 samples shares interferon
- GSE281902 Periosteum Signatures of Delayed Fracture Healing in Type 2 Diabetes at Single-Cell Resolution 5 samples shares signatures
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.