← BioTransfer GEO Dataset Finder
GEO series

Active DNA demethylation is upstream of rod photoreceptor fate determination and required for retinal development [RNA-Seq]

GSE288096 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/03/01 Platform GPL34290
Summary
The goal of this study is to investigate the role of TET enzyme-mediated DNA demethylation on retinal development and cell fate specification. We utilized an allelic series of TET enzyme retinal conditional mouse mutants using the Chx10-Cre-GFP transgene, removing the TET enzymes from retinal progenitor cells. We observe that inhibition of DNA demethylation results in abnormal retinal development and a loss of visual function. Immunohistological and genomic profiling (RNA-seq, scRNA-seq, WGBS, and bACE-seq) indicate that rod photoreceptor gene regulatory networks are inhibited when DNA demethylation is lost, indicating that DNA demethylation is required for NRL and NR2E3 expression, resulting in a retina with increased specification of cone photoreceptors.
Published in
Active DNA demethylation is upstream of rod-photoreceptor fate determination and required for retinal development
Hernández-Núñez I, Urman A, Zhang X et al. · bioRxiv : the preprint server for biology 2025 · PMID 39975078 · doi:10.1101/2025.02.03.636318
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE288096_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1216196 and SRA study SRP560109. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.