Comparative gene expression profiling of RNA-seq data from islets of β-cell-specific ZZEF1 knockout mice (βZKO-Mip) and their littermate controls, treated with either azoramide or DMSO.
RNA-seq (gene expression) · mouse · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 3 × βZKO_Mip Azoramide vs 3 × control Azoramide vs 2 × control DMSOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetesNature metabolism · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288210_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1216579 and SRA study SRP560468. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 3 replicated groups read from 11 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8761300 βZKO_Mip Azoramide rep1 βZKO_Mip Azoramide
- GSM8761301 βZKO_Mip Azoramide rep2 βZKO_Mip Azoramide
- GSM8761302 βZKO_Mip Azoramide rep3 βZKO_Mip Azoramide
- GSM8761303 βZKO_Mip DMSO rep1
- GSM8761304 βZKO_Mip DMSO rep2
- GSM8761305 control Azoramide rep1 control Azoramide
- GSM8761306 control Azoramide rep2 control Azoramide
- GSM8761307 control Azoramide rep3 control Azoramide
- GSM8761308 control DMSO rep1
- GSM8761309 control DMSO rep2 control DMSO
- GSM8761310 control DMSO rep3 control DMSO
- GSE273688 Gene expression profile at single cell level of islets from two β-cell specific knockout mouse models (βZKO-Mip and βZKO-Rip), littermate controls (Zzef1f/f), and the MIP-Cre mice fed with normal-chow diet (NCD). 8 samples shares zzef1, littermate, knockout, controls
- GSE223143 Gene expression data of islets from Zzef1 global knockout (Zzef1_KO) mice and littermate controls (WT) mice fed with normal-chow diet (NCD) [bulk RNA-seq] 7 samples shares zzef1, littermate, knockout, controls
- GSE295845 The RNA-Seq of PCK1 intestinal epithelial cell-specific knockout mice and their littermate control mice 12 samples shares cell-specific, littermate, knockout
- GSE250140 Comparative translating ribosome affinity purification-RNAseq (TRAPseq) by lung cell-specific drivers 49 samples shares cell-specific, comparative
- GSE303929 Comparative Transcriptomic Analysis of Embryonic Hearts in Atf4 Exon 2 and Exon 2–3 Conditional Knockout Mice 16 samples shares comparative, knockout
- GSE232888 Effect of endothelial cell-specific TET2 knockout on mouse lung endothelial cell transcriptome of chow-fed and high fat diet-fed mice 12 samples shares cell-specific, knockout
- GSE270908 Comparative transcriptomic analysis of pre-plasma germinal center B cells in wild type and Kdm6b B knockout models 12 samples shares comparative, knockout
- GSE311308 Comparison of the kidney transcriptome of 28 days old principal cell-specific Tsc1 knockout (Tsc1f/f/Aqp2 Cre) vs wild-type (WT) mice 8 samples shares cell-specific, knockout
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.