Targeting Setdb1 in T Cells Induces Transplant Tolerance without Compromising Antitumor Immunity
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 16 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting Setdb1 in T cells induces transplant tolerance without compromising antitumor immunityNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288264_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1216646 and SRA study SRP560461. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 8 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8762491 SETDB1 WT control rep1 SETDB1 WT control
- GSM8762492 SETDB1 WT control rep2 SETDB1 WT control
- GSM8762493 SETDB1 WT HT rep1 SETDB1 WT HT
- GSM8762494 SETDB1 WT HT rep2 SETDB1 WT HT
- GSM8762495 SETDB1 KO control rep1 SETDB1 KO control
- GSM8762496 SETDB1 KO control rep2 SETDB1 KO control
- GSM8762497 SETDB1 KO HT rep1 SETDB1 KO HT
- GSM8762498 SETDB1 KO HT rep2 SETDB1 KO HT
- GSM8762499 H3K9ME3 WT control rep1 H3K9ME3 WT control
- GSM8762500 H3K9ME3 WT control rep2 H3K9ME3 WT control
- GSM8762501 H3K9ME3 WT HT rep1 H3K9ME3 WT HT
- GSM8762502 H3K9ME3 WT HT rep2 H3K9ME3 WT HT
- GSM8762503 H3K9ME3 KO control rep1 H3K9ME3 KO control
- GSM8762504 H3K9ME3 KO control rep2 H3K9ME3 KO control
- GSM8762505 H3K9ME3 KO HT rep1 H3K9ME3 KO HT
- GSM8762506 H3K9ME3 KO HT rep2 H3K9ME3 KO HT
- GSE270414 Precision targeting of beta-catenin induces tumor reprogramming and immunity in hepatocellular cancers [Bulk RNA-seq CTNNB1/hMet/NFE2L2] 13 samples shares targeting, immunity, induces
- GSE272424 Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages 6 samples shares targeting, antitumor, immunity
- GSE222227 Induced regulatory B cells stably expressing IL-10 cure CNS autoimmunity by targeting microglia 22 samples shares targeting, immunity
- GSE252269 Targeting the FOXP3–T-bet interaction to restore Treg stability in IFN-γ–driven autoimmunity [CUT&Tag/ATAC-seq] 18 samples shares targeting, immunity
- GSE281467 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TIICs RNA-seq] 30 samples shares targeting, induces
- GSE281466 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TME RNA-seq] 18 samples shares targeting, induces
- GSE252337 Dysfunction of infiltrating cytotoxic CD8+ T cells within the graft promotes murine kidney allotransplant tolerance 16 samples shares transplant, tolerance
- GSE251931 Maintenance of tolerance after lung transplantation is dependent on the preservation of allograft tissue-resident Foxp3+ T cells 15 samples shares transplant, tolerance
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.