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RNA-seq analysis of E11.5 and E12.5 Mboat7 KO cortices

GSE288356 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/02/04 Platform GPL24247Platform GPL34290
Summary
To investigate whether Mboat7 KO mice showed any abnormality before E11.5, we evaluated the global gene expression patterns in the cortices of Mboat7 heterozygous mice and KO mice at E11.5 using RNA-sequencing. No significant differences in gene expression were observed, suggesting that Mboat7 KO mice develop normally until E11.5. Even at E12.5 when the phenotype starts to become apparent, little difference in gene expression were observed in Mboat7 KO mice.
Published in
LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex
Ishino Y, Kishi Y, Iwama T et al. · iScience 2026 · PMID 41488780 · doi:10.1016/j.isci.2025.114248
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Also filed as BioProject PRJNA1217008 and SRA study SRP560621. Searching any of these in the dataset finder brings you back here.

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