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Effects of IFN beta treatment on gene expression in human fibrosarcoma HT1080 cells

GSE288379 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/04 Platform GPL24676
Summary
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a cytosolic DNA sensing system. The pathway product interferon-β (IFNβ) can inhibit tumor cell growth, but it remains unclear whether ferroptosis is involved in IFNβ-induced cell death. We found that IFNβ can increase intracellular Fe2+ and lipid peroxidation levels while decreasing GSH levels in tumor cells. RNA sequencing data showed that IFNβ caused abnormal transcriptional expression of ferroptosis-related genes in HT1080 cells, with upregulation of multiple genes including TRIM21, PML, PARP9, PARP14, and PARP10. These results indicate that ferroptosis is involved in IFNβ-induced tumor cell ferroptosis.
Published in
IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3
Dong H, Zhu L, Sun J et al. · Frontiers in immunology 2025 · PMID 39975542 · doi:10.3389/fimmu.2025.1535554
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Also filed as BioProject PRJNA1217059 and SRA study SRP560654. Searching any of these in the dataset finder brings you back here.

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