Bulk mRNAseq in control and Plp-CreER_Ddx20 cKO mouse spinal cords
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × 4W_Ctrl vs 3 × 4W_Ddx20cKO vs 3 × 4.5W_Ctrl vs 3 × 4.5W_Ddx20cKOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- An inducible oligodendrocyte dysfunction triggered a pathological cascade of massive microglial activation and neurodegenerationNeurobiology of disease · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE288387_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1217338 and SRA study SRP560703. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8766657 4W_Ctrl1 4W_Ctrl
- GSM8766658 4W_Ctrl2 4W_Ctrl
- GSM8766659 4W_Ctrl3 4W_Ctrl
- GSM8766660 4W_Ddx20cKO1 4W_Ddx20cKO
- GSM8766661 4W_Ddx20cKO2 4W_Ddx20cKO
- GSM8766662 4W_Ddx20cKO3 4W_Ddx20cKO
- GSM8766663 4.5W_Ctrl1 4.5W_Ctrl
- GSM8766664 4.5W_Ctrl2 4.5W_Ctrl
- GSM8766665 4.5W_Ctrl3 4.5W_Ctrl
- GSM8766666 4.5W_Ddx20cKO1 4.5W_Ddx20cKO
- GSM8766667 4.5W_Ddx20cKO2 4.5W_Ddx20cKO
- GSM8766668 4.5W_Ddx20cKO3 4.5W_Ddx20cKO
- GSE233491 Bulk TCR-sequencing of various tissues in mice treated with 2% DSS or H2O control. 45 samples shares control, bulk
- GSE276628 Reciprocal genetic screens identify epigenetics factors controlling epidermal cell activation. [RNAseq_MiniBulk] 41 samples shares control, bulk
- GSE271650 Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [bulk RNA-seq] 18 samples shares control, bulk
- GSE311539 Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility (Bulk-RNAseq) 10 samples shares control, bulk
- GSE205285 Mouse single positive thymocyte bulk RNA-seq from Kmt2d knockout and control littermates. 18 samples shares control, bulk
- GSE301327 RiboTag and bulk RNA sequencing using AAV-Control and AAV-shLarp1 infected sensory neurons. 12 samples shares control, bulk
- GSE301320 RiboTag and bulk RNA sequencing using AAV-Control and AAV-shCsde1 infected sensory neurons. 12 samples shares control, bulk
- GSE269191 ZEB2 is a Master Switch Controlling the Tumor-Associated Macrophage Program [in vivo] 145 samples shares control
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.