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Olfr2 drives abdominal aortic aneurysm by promoting monocyte recrutiment

GSE288404 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/09 Platform GPL34290
Summary
Olfactory receptor 2 is a G-protein coupled receptor expressed on vascular macrophages. Activation by its ligand octanal in conjuction with a toll like receptor 4 stimulus induces the NLRP3 inflammasome with subsequent IL-1alpha and IL-1beta release. In this study we aim to investigate the effects of genetic Olfr2 deficiency on the development of abdominal aortic aneurysm (AAA).
Published in
Olfr2 Promotes Recruitment of Monocytes via CX3CR1 in Abdominal Aortic Aneurysm
Schelemei P, Picard FSR, Park Y et al. · Circulation research 2026 · PMID 41473953 · doi:10.1161/CIRCRESAHA.125.326591
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Also filed as BioProject PRJNA1217385 and SRA study SRP560729. Searching any of these in the dataset finder brings you back here.

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