← BioTransfer GEO Dataset Finder
GEO series

Effect of HNF1A-MODY on stem cell islets [scRNA-seq]

GSE288431 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/03/30 Platform GPL24676
Summary
This project investigates the impact of the hotspot mutation P291fsinsC in HNF1A-MODY (Maturity-Onset Diabetes of the Young) on stem cell-derived islets. RNA sequencing (RNA-seq) was performed on islets differentiated from mutant and control HNF1A-MODY stem cells to study the mutation's effect on gene expression. By comparing the transcriptomic profiles of these islets, the study aims to uncover molecular mechanisms underlying the dysfunction caused by the P291fsinsC mutation during islet development and maturation.
Published in
Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo
Unger L, Larsen U, Legøy TA et al. · Genes & development 2026 · PMID 41887801 · doi:10.1101/gad.353153.125
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE288431_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1217453 and SRA study SRP560804. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.